Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study The TODAY Study Group

被引：61

作者：

Wilfley, D. E. ^{[20
]}

Haymond, M. ^{[1
]}

Anderson, B. ^{[1
]}

Gunn, S. ^{[1
]}

Holden, H. ^{[1
]}

Jones, M. ^{[1
]}

Hwu, K. ^{[1
]}

McGirk, S. ^{[1
]}

Mckay, S. ^{[1
]}

Schreiner, B. ^{[1
]}

Cuttler, L. ^{[2
]}

Abrams, E. ^{[2
]}

Casey, T. ^{[2
]}

Dahms, W. ^{[2
]}

Drotar, D. ^{[2
]}

Huestis, S. ^{[2
]}

Levers-Landis, C. ^{[2
]}

McGuigan, P. ^{[2
]}

Sundararajan, S. ^{[2
]}

Geffner, M. ^{[3
]}

Chang, N. ^{[3
]}

Dreimane, D. ^{[3
]}

Halvorson, M. ^{[3
]}

Hernandez, S. ^{[3
]}

Kaufman, F. ^{[3
]}

Mansilla, V. ^{[3
]}

Ortiz, R. ^{[3
]}

Ward, A. ^{[3
]}

Wexler, K. ^{[3
]}

Yasuda, P. ^{[3
]}

Katz, L. Levitt ^{[4
]}

Berkowitz, R. ^{[4
]}

Boyd, S. ^{[4
]}

Carchidi, C. ^{[4
]}

Kaplan, J. ^{[4
]}

Keating, C. ^{[4
]}

Kneeshaw-Price, S. ^{[4
]}

Lassiter, C. ^{[4
]}

Lipman, T. ^{[4
]}

Magge, S. ^{[4
]}

McGinley, G. ^{[4
]}

Schwartzman, B. ^{[4
]}

Willi, S. ^{[4
]}

Arslanian, S. ^{[5
]}

Bacha, F. ^{[5
]}

Foster, S. ^{[5
]}

Galvin, B. ^{[5
]}

Hannon, T. ^{[5
]}

Kriska, A. ^{[5
]}

Libman, I. ^{[5
]}

机构：

[1] Baylor Coll Med, Ctr Clin, Houston, TX 77030 USA

[2] Case Western Reserve Univ, Cleveland, OH 44106 USA

[3] Childrens Hosp Los Angeles, Los Angeles, CA USA

[4] Childrens Hosp Philadelphia, Philadelphia, PA USA

[5] Childrens Hosp Pittsburgh, Pittsburgh, PA USA

[6] Columbia Univ, Med Ctr, New York, NY 10027 USA

[7] Massachusetts Gen Hosp, Boston, MA 02114 USA

[8] St Louis Univ, St Louis, MO 63103 USA

[9] SUNY Upstate Med Univ, Syracuse, NY USA

[10] Univ Colorado, Hlth Sci Ctr, Boulder, CO 80309 USA

[11] Univ Oklahoma, Hlth Sci Ctr, Norman, OK 73019 USA

[12] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA

[13] Washington Univ, Sch Med, St Louis, MO 63130 USA

[14] Yale Univ, New Haven, CT 06520 USA

[15] Washington Univ, Ctr Biostat, Coordinating Ctr George, St Louis, MO 63130 USA

[16] NIDDK, Project Off, Bethesda, MD 20892 USA

[17] Univ Washington, NW Lipid Res Labs, Cent Units Cent Blood Lab, Seattle, WA 98195 USA

[18] Univ Calif San Francisco, DEXA Reading Ctr, San Francisco, CA 94143 USA

[19] Univ S Carolina, Diet Assessment Ctr, Columbia, SC 29208 USA

[20] Washington Univ, Lifestyle Program Core, St Louis, MO 63130 USA

[21] Ctr Dis Control, Atlanta, GA 30333 USA

[22] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[23] SUNY Buffalo, Buffalo, NY 14260 USA

[24] Univ Florida, Gainesville, FL 32611 USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2010年 / 34卷 / 02期

关键词：

pediatric; chronic illness; childhood obesity; adolescents; LONG-TERM MANAGEMENT; ADOLESCENT OVERWEIGHT; PEDIATRIC OBESITY; WEIGHT-LOSS; CHILDHOOD OVERWEIGHT; SEDENTARY BEHAVIOR; COST-EFFECTIVENESS; GLYCEMIC LOAD; PREVENTION; DIET;

D O I：

10.1038/ijo.2009.195

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes is associated with obesity and is increasing at an alarming rate in youth. Although weight loss through lifestyle change is one of the primary treatment recommendations for adults with type 2 diabetes, the efficacy of this approach has not been tested with youth. This paper provides a summary of the reviews and meta-analyses of pediatric weight-loss interventions that informed the design and implementation of an intensive, family-based lifestyle weight management program for adolescents with type 2 diabetes and their families developed for the Treatment Options for type 2 Diabetes in Adolescents and Youth ( TODAY) study. A total of 1092 youth have been screened, and 704 families have been randomized for inclusion in this 15-center clinical trial sponsored by the National Institutes of Health. The TODAY study is designed to test three approaches ( metformin, metformin plus rosiglitazone and metformin plus an intensive lifestyle intervention) to the treatment of a diverse cohort of youth, 10-17 years of age, within 2 years of their diagnosis. The principal goal of the TODAY Lifestyle Program (TLP) is to decrease baseline weight of youth by 7-10% ( or the equivalent for children who are growing in height) through changes in eating and physical activity habits, and to sustain these changes through ongoing treatment contact. The TLP is implemented by interventionists called Personal Activity and Nutrition Leaders (PALs) and delivered to youth with type 2 diabetes, and at least one family support person. The TLP provides a model for taking a comprehensive, continuous care approach to the treatment of severe overweight in youth with comorbid medical conditions such as type 2 diabetes. International Journal of Obesity (2010) 34, 217-226; doi: 10.1038/ijo.2009.195; published online 13 October 2009

引用

页码：217 / 226

页数：10

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