A stereospecific synthesis of both enantiomers of 2-(1'-amino-2'-methylpropyl) imidazole, a key synthon in the synthesis of SB 203386; A potent protease inhibitor

被引：25

作者：

Pridgen, LN

Mokhallalati, MK

McGuire, MA

机构：

[1] Synthetic Chemistry Department, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)00070-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two methods for the asymmetric synthesis of both enantiomers of 2-(1'-amino-2'-methylpropyl)imidazole (2) have been developed by adding nucleophilic organometallics to nonracemic 2-oxazolidinones employing 2-phenylglycinol as the source of chirality. Excellent stereochemical yields were obtained. (C) 1997 Elsevier Science Ltd.

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收藏

页码：1275 / 1278

页数：4

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