Murine natural killer cell progenitors and their requirements for development

被引：47

作者：

Lian, RH ^{[1
]}

Kumar, V ^{[1
]}

机构：

[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

SEMINARS IN IMMUNOLOGY | 2002年 / 14卷 / 06期

关键词：

development; NK; progenitor; knock-out; differentiation;

D O I：

10.1016/S1044532302000805

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Molecules that are essential to natural killer (NK) cell development have been identified mostly through characterizing knock-out mice that exhibit NK deficiencies. Such studies have shown that the interaction of membrane lymphotoxin (LT) on NK cells with its receptor on stromal elements is necessary for inducing a permissive microenvironment for NK development. Also, transcription factors such as Id2, interferon regulatory factors-1 (IRF-1), IRF-2, and Ets-1 are indispensable while PU.1 has a somewhat selective role. In addition, recent studies have identified T/NK progenitors (T/NKPs) in the fetal liver that precede migration to the fetal thymus as well as the earliest committed NK precursors in the bone marrow.

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收藏

页码：453 / 460

页数：8

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