No one is naive: The significance of heterologous T-cell immunity

被引：375

作者：

Welsh, RM ^{[1
]}

Selin, LK ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri820

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Memory T cells that are specific for one virus can become activated during infection with an unrelated heterologous virus, and might have roles in protective immunity and immunopathology. The course of each infection is influenced by the T-cell memory pool that has been laid down by a host's history of previous infections, and with each successive infection, T-cell memory to previously encountered agents is modified. Here, we discuss evidence from studies in mice and humans that shows the importance of this phenomenon in determining the outcome of infection.

引用

页码：417 / 426

页数：10

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