Glutamine-enriched enteral diet enhances bacterial clearance in protracted bacterial peritonitis, regardless of glutamine form

被引：20

作者：

Furukawa, S ^{[1
]}

Saito, H ^{[1
]}

Inaba, T ^{[1
]}

Lin, MT ^{[1
]}

Inoue, T ^{[1
]}

Naka, S ^{[1
]}

Fukatsu, K ^{[1
]}

Hashiguchi, Y ^{[1
]}

Han, I ^{[1
]}

Matsuda, T ^{[1
]}

Ikeda, S ^{[1
]}

Muto, T ^{[1
]}

机构：

[1] UNIV TOKYO,SURG CTR,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | 1997年 / 21卷 / 04期

关键词：

D O I：

10.1177/0148607197021004208

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: The effects of glutamine (Gln)-enriched enteral diets on bacterial clearance were investigated in a rat protracted peritonitis model. The effects of the Gln form, peptide-based vs free amino acid-based, were also compared. Methods: Twenty-three rats underwent gastrostomy. An osmotic pump was implanted in the peritoneal cavity. The rats received a continuous intragastric infusion of one of three diets: Gln-depleted (Gln 0), Gln-enriched with the Gln in free amino acid form (Gln F), or Gin-enriched with the Gln in oligopeptide form (Gln P); The three formulas were isocaloric and isonitrogenous. The pumps delivered a continuous infusion of Escherichia coli, starting at 48 hours after implantation, for 24 hours. Then, the animals were killed. Results: Bacterial numbers in peritoneal lavaged fluid (PLF) and the liver were significantly lower in the Gln P and Gln F groups than in the Gln 0 group. The bacterial number in PLF correlated with that in the liver. Neither the number nor the population of peritoneal exudative cells differed among groups. Plasma levels of proline, alanine and citrulline were significantly higher in the Gln P and Gln F groups than in the Gln 0 group. Both Gln supplemented groups showed significantly greater villous height, crypt depth, and numbers of mitoses per crypt in the small intestine than the Gln 0 group. Conclusions: Supplemental Gln enhances peritoneal and hepatic bacterial clearance, regardless of Gln form. Gln-enriched may be more beneficial than Gln-depleted enteral diets in peritonitis.

引用

页码：208 / 214

页数：7

共 23 条

[1] A NEW MODEL FOR STUDYING NUTRITION IN PERITONITIS - THE ADVERSE EFFECT OF OVERFEEDING [J].