The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet

被引：42

作者：

Arum, Oge ^{[1
]}

Bonkowski, Michael S. ^{[1
]}

Rocha, Juliana S. ^{[2
]}

Bartke, Andrzej ^{[1
]}

机构：

[1] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA

[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Morphol, Lab Cellular Biol, Belo Horizonte, MG, Brazil

来源：

AGING CELL | 2009年 / 8卷 / 06期

关键词：

aging; caloric restriction; growth hormone; insulin sensitivity; intermittent fasting; longevity; LIFE-SPAN; CALORIE RESTRICTION; TARGETED DISRUPTION; SEXUAL-DIMORPHISM; MICE; LONGEVITY; INSULIN; AGE; MECHANISMS; BIOMARKERS;

D O I：

10.1111/j.1474-9726.2009.00520.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

P>The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric restriction, in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction, we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting diet. The intermittent fasting diet increased the survivorship and improved insulin sensitivity of normal males, but failed to affect either parameter in GHR-KO mice. From the results of two paradigms of dietary restriction, we postulate that GHR-KO mice would be resistant to any manner of dietary restriction; potentially due to their inability to further enhance insulin sensitivity. Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention.

引用

页码：756 / 760

页数：5

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