Relationship between mRNA stability and length: An old question with a new twist

被引：48

作者：

Feng, Liang ^{[1
]}

Niu, Deng-Ke ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Biodivers Sci & Ecol Engn, Beijing 100875, Peoples R China

来源：

BIOCHEMICAL GENETICS | 2007年 / 45卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

mRNA half-life; mRNA-decay rate; mRNA length; mRNA degradation;

D O I：

10.1007/s10528-006-9059-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The half-life of individual mRNA plays a central role in controlling the level of gene expression. However, the determinants of mRNA stability have not yet been well defined. Most previous studies suggest that mRNA length does not affect its stability. Here, we show significant negative correlations between mRNA length and stability in human and Escherichia coli, but not in Saccharomyces cerevisiae or Bacillus subtilis. This finding suggests the possibility that endonucleolytic attacks by RNA endonuclease and/or mechanical damage may strongly influence mRNA stability in both prokaryotes and eukaryotes.

引用

页码：131 / 137

页数：7

共 26 条

[1]

[Anonymous], 2002, GENOMES

[2]

Global analysis of Escherichia coli RNA degradosome function using DNA microarrays [J].