In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457

被引：17

作者：

Foleno, Barbara D. ^{[1
]}

Abbanat, Darren

Goldschmidt, Raul M.

Flamm, Robert K.

Paget, Steve D.

Webb, Glenda C.

Wira, Ellyn

Macielag, Mark J.

Bush, Karen

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Raritan, NJ 08869 USA

[2] Focus Bio Inova,Inc, Herndon, VA 20171 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 01期

关键词：

D O I：

10.1128/AAC.01017-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of <= 4 mu g/ml, generally exhibiting two- to fourfold-greater potency than that of linezolid. Time-kill studies demonstrated bacteriostatic effects for both RWJ-416457 and linezolid.

引用

页码：361 / 365

页数：5

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