Melohenines A and B, Two Unprecedented Alkaloids from Melodinus henryi

被引：79

作者：

Feng, Tao ^{[1
,2
]}

Cai, Xiang-Hai ^{[1
]}

Li, Yan ^{[1
]}

Wang, Yuan-Yuan ^{[1
]}

Liu, Ya-Ping ^{[1
,2
]}

Xie, Ming-Jin ^{[3
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 21期

基金：

中国国家自然科学基金;

关键词：

MONOTERPENOID INDOLE ALKALOIDS; ALSTONIA-SCHOLARIS; NATURAL-PRODUCTS; DES STRYCHNINS; CHEMISTRY; CAMPTOTHECIN; SCANDENS; CORE;

D O I：

10.1021/ol9018826

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A phytochemical study on Melodinus henryi has led to the Isolation of two novel alkaloids, melohenines A (1), a monoterpenoid indole alkaloid with additional skeletal carbons arranged compactly in eight rings, and melohenine B (2), an alkaloid with an unprecedented 6/9/6/6 tetracyclic ring system regarded as a key intermediate from indole to quinoline alkaloids. Their structures were elucidated by means of spectroscopic methods and further confirmed by X-ray diffraction analysis.

引用

收藏

页码：4834 / 4837

页数：4

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