The effect of apolipoprotein polymorphism on brain in mild cognitive impairment:: A voxel-based morphometric study

被引：16

作者：

Pennanen, Corina

Testa, Cristina

Boccardi, Marina

Laakso, Mikko P.

Hallikainen, Merja

Helkala, Eeva-Liisa

Hanninen, Tuomo

Kivipelto, Miia

Kononen, Mervi

Nissinen, Aulikki

Tervo, Susanna

Vanhanen, Matti

Vanninen, Ritva

Frisoni, Giovani B.

Soininen, Hilkka

机构：

[1] Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

[3] Kuopio Univ Hosp, Dept Clin Radiol, SF-70210 Kuopio, Finland

[4] Univ Kuopio, Dept Publ Hlth, FIN-70211 Kuopio, Finland

[5] Natl Inst Publ Hlth, Helsinki, Finland

[6] IRCCS San Giovanni Dio FBF, Lab Epidemiol & Neuroimaging, Brescia, Italy

[7] Assoc Fatebenefratelli Ric, Rome, Italy

[8] Univ Udine, Dept Math & Comp Sci, Machine Vis Lab, I-33100 Udine, Italy

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2006年 / 22卷 / 01期

关键词：

apolipoprotein E; mild cognitive impairment; Alzheimer's disease; magnetic resonance imaging; voxel-based morphometry; hippocampus; entorhinal cortex; amygdala; thalamus;

D O I：

10.1159/000093263

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated the effect of apolipoprotein E ( ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon 4 ( n = 15) and those who were ApoE epsilon 4 noncarriers ( n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the epsilon 4 allele ( n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus. Copyright (C) 2006 S. Karger AG, Basel.

引用

页码：60 / 66

页数：7

共 60 条

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