Cutting edge: Down-regulation of MICA on human tumors by proteolytic shedding

被引：529

作者：

Salih, HR

Rammensee, HG

Steinle, A

机构：

[1] Univ Tubingen Hosp, Dept Internal Med 2, Tubingen, Germany

[2] Univ Tubingen, Dept Immunol, Tubingen, Germany

来源：

JOURNAL OF IMMUNOLOGY | 2002年 / 169卷 / 08期

关键词：

D O I：

10.4049/jimmunol.169.8.4098

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunoreceptor NKG2D stimulates tumor immunity through activation of CD8 T cells and NK cells. Its ligand MICA has been shown to be broadly expressed on human tumors of epithelial origin. MICA expression correlates with an enrichment of Vdelta1 T cells in tumor tissue. We report that human tumor cells spontaneously release a soluble form of MICA encompassing the three extracellular domains, which is present at high levels in sera of patients with gastrointestinal malignancies; but not in healthy donors. Release of MICA from tumor cells is blocked by inhibition of metalloproteinases, concomitantly causing accumulation of MICA on the cell surface. Shedding of MICA by tumor cells may modulate NKG2D-mediated tumor immune surveillance. In addition, determination of soluble MICA levels may be implemented as an immunological diagnostic marker in patients with epithelial malignancies.

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页码：4098 / 4102

页数：5

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