Digitalis; impinges on more than just the (ion-) pump

被引：9

作者：

Haux, J ^{[1
]}

机构：

[1] St Olavs Univ Hosp, Dept Oncol, N-7006 Trondheim, Norway

来源：

MEDICAL HYPOTHESES | 2002年 / 59卷 / 06期

关键词：

D O I：

10.1016/S0306-9877(02)00334-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Some forms of digitalis, such as digitoxin, inhibits proliferation and induces apoptosis in cancer cells in clinically relevant concentrations. Recently, it has been demonstrated that digitalis, in addition to inhibiting the Na+/K+-ATPase, also signals through the pathways of the epidermal growth factor receptor (EGFR). Digitalis has complex dose-dependent mechanisms of action involving many signaling systems and the relevance of this for the anticancer effects are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：781 / 782

页数：2

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