Calcific aortic stenosis: same old story?

被引:52
作者
Cowell, SJ
Newby, DE
Boon, NA
Elder, AT
机构
[1] Royal Infirm, Dept Cardiol, Edinburgh EH16 4SA, Midlothian, Scotland
[2] Royal Infirm, Edinburgh EH16 4SB, Midlothian, Scotland
[3] Western Gen Hosp, Dept Med Elderly, Edinburgh EH4 2XU, Midlothian, Scotland
关键词
aortic stenosis; aetiology; pathogenesis; management; medical therapy; elderly;
D O I
10.1093/ageing/afh175
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 [法学]; 0303 [社会学]; 100203 [老年医学];
摘要
Calcific aortic stenosis is the commonest adult valvular heart condition seen in the western world. Its prevalence is continuing to rise, with predominance in older patients who are frequently undergoing successful aortic valve replacement. This review discusses the natural history of calcific aortic stenosis, highlights recent insights into its pathogenesis, and outlines current medical and surgical management. The potential role of novel therapeutic interventional strategies is discussed.
引用
收藏
页码:538 / 544
页数:7
相关论文
共 30 条
[1]
Why do so few older people with aortic stenosis have valve replacement surgery? [J].
Abdul-Hamid, AR ;
Mulley, GP .
AGE AND AGEING, 1999, 28 (03) :261-264
[2]
Association of cholesterol levels, hydroxymethylglutaryl coenzyme-A reductase inhibitor treatment, and progression of aortic stenosis in the community [J].
Bellamy, MF ;
Pellikka, PA ;
Klarich, KW ;
Tajik, AJ ;
Enriquez-Sarano, M .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (10) :1723-1730
[3]
ACC/AHA guidelines for the management of patients with valvular heart disease - A report of the American College of Cardiology American Heart Association Task Force on practice guidelines (Committee on Management of Patients with Valvular Heart Disease) [J].
Bonow, RO ;
Carabello, B ;
De Leon, AC ;
Edmunds, LH ;
Fedderly, BJ ;
Freed, MD ;
Gaasch, WH ;
Mckay, CR ;
Nishimura, RA ;
O'Gara, PT ;
O'Rourke, RA ;
Rahimtoola, SH .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (05) :1486-1582
[4]
To operate or not on elderly patients with aortic stenosis: the decision and its consequences [J].
Bouma, BJ ;
van den Brink, RBA ;
van der Meulen, JHP ;
Verheul, HA ;
Cheriex, EC ;
Hamer, HPM ;
Dekker, E ;
Lie, KI ;
Tijssen, JGP .
HEART, 1999, 82 (02) :143-148
[5]
Evaluation and management of patients with aortic stenosis [J].
Carabello, BA .
CIRCULATION, 2002, 105 (15) :1746-1750
[6]
CHUI MC, 1999, HEART, V81, P171
[7]
Aortic valve calcification on computed tomography predicts the severity of aortic stenosis [J].
Cowell, SJ ;
Newby, DE ;
Burton, J ;
White, A ;
Northridge, DB ;
Boon, NA ;
Reid, J .
CLINICAL RADIOLOGY, 2003, 58 (09) :712-716
[8]
A SKELETON IN THE ATHEROSCLEROSIS CLOSET [J].
DEMER, LL .
CIRCULATION, 1995, 92 (08) :2029-2032
[9]
Cholesterol in vascular and valvular calcification [J].
Demer, LL .
CIRCULATION, 2001, 104 (16) :1881-1883
[10]
Progression of aortic valve sclerosis to aortic stenosis [J].
Faggiano, P ;
Antonini-Canterin, F ;
Erlicher, A ;
Romeo, C ;
Cervesato, E ;
Pavan, D ;
Piazza, R ;
Huang, GQ ;
Nicolosi, GL .
AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (01) :99-+