Synthesis and characterization of organotin substituted heteropolytungstophosphates and their biological activity

被引：37

作者：

Wang, XH ^{[1
]}

Liu, JF ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2000年 / 51卷 / 01期

基金：

中国国家自然科学基金;

关键词：

antitumour activity; organotin; Keggin structure; Dawson structure; synthesis;

D O I：

10.1080/00958970008047080

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organotin-substituted Keggin or Dawson tungstophosphates [(CH3OOCCH2CH2Sn)(3)-(PW9O34)(2)](9-), [(CH3OOCCH2CH2Sn)P2W17O61](7-), [(CH3OOCCH2CH2Sn)P2W17O61](7-), [(CH3OOCCH(CH3)CH2Sn)(3)(PW9O34)(2)](9-), [(CH3OOCCH(CH3)CH2Sn)PW11O39](4-) and [(CH3OOCCH(CH3)CH2Sn)P2W17O61](7-) have been prepared by reactions of the beta-methoxycarbonylethyltin, beta-methoxycarbonyl-i-propyltin trichlorides with PW9O349-, PW11O397- and P2W17O6110-, respectively. The products were isolated as K+, and Bu4N+ salts, and were characterized by means of elemental analysis, IR H-1 NMR, W-183 NMR and Sn-119 NMR spectra, and polarography. The antitumour activity of the complexes as investigated and the effect of the polyanions and estertin on antitumour activity was examined.

引用

页码：73 / 82

页数：10

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