BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
|
2002年
/
1592卷
/
03期
基金:
以色列科学基金会;
关键词:
cytokine;
liver;
regeneration;
stem cells;
D O I:
10.1016/S0167-4889(02)00326-9
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The liver is a unique organ, and first in line, the hepatocytes encounter the potential to proliferate during cell mass loss. This phenomenon is tightly controlled and resembles in some way the embryonal co-inhabitant cell lineage of the liver, the embryonic hematopoietic system. Interestingly, both the liver and hematopoietic cell proliferation and growth are controlled by various growth factors and cytokines. IL-6 and its signaling cascade inside the cells through STAT3 are both significantly important for liver regeneration as well as for hematopoietic cell proliferation. The process of liver regeneration. is very complex and is dependent on the etiology and extent of liver damage and the genetic background. In this review we will initially describe the clinical relevant condition, portraying a number of available animal models with an emphasis on the relevance of each one to the human condition of fulminant hepatic failure (FHF). The discussion will then be focused on the role of cytokines in liver failure and regeneration, and suggest potential new therapeutic modalities for FHF. The recent findings on the role of IL-6 in liver regeneration and the activity of the designer IL-6/sIL-6R fusion protein, hyper-IL-6, in particular, suggest that this molecule could significantly enhance liver regeneration in humans, and as such could be a useful treatment for FHF in patients. (C) 2002 Elsevier Science B.V. All rights reserved.
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
Arkadopoulos, N
;
Detry, O
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
Detry, O
;
Rozga, J
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
Rozga, J
;
Demetriou, AA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
机构:Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, Australia
Bowen, DG
;
Shackel, NA
论文数: 0引用数: 0
h-index: 0
机构:Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, Australia
Shackel, NA
;
McCaughan, GW
论文数: 0引用数: 0
h-index: 0
机构:
Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, AustraliaRoyal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, Australia
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
Arkadopoulos, N
;
Detry, O
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
Detry, O
;
Rozga, J
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
Rozga, J
;
Demetriou, AA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Dept Surg, Sch Med,Liver Support Unit, Los Angeles, CA 90048 USA
机构:Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, Australia
Bowen, DG
;
Shackel, NA
论文数: 0引用数: 0
h-index: 0
机构:Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, Australia
Shackel, NA
;
McCaughan, GW
论文数: 0引用数: 0
h-index: 0
机构:
Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, AustraliaRoyal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Camperdown, NSW, Australia