Hypernatremic suppression of neutrophils

被引:14
作者
Kuroda, T [1 ]
Harada, T [1 ]
Tsutsumi, H [1 ]
Kobayashi, M [1 ]
机构
[1] SAITAMA MED CTR,SAITAMA MED SCH,DEPT EMERGENCY & CRIT CARE MED,KAWAGOE,SAITAMA 350,JAPAN
关键词
neutrophils; hypernatremia; zone of stasis; phagocytosis; superoxide production;
D O I
10.1016/S0305-4179(96)00134-9
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Phagocytic and bactericidal activities are important functions of the human polymorphonuclear leucocytes (PMNL) as the host defence against burn wound infection. The zone of stasis, just below the zone of coagulation, is a sige of interaction between invading bacteria and PMNL. For many reasons the osmotic pressure at this site is elevated. In this study we evaluated the in vitro phagocytic and bactericidal activities of PMNL under hypernatremic conditions. At a sodium concentration of 180 mEq/l, phagocytic activity was suppressed. Although on average superoxide production was maintained within the normal range, it was suppressed in three of the ten cases studied. We conclude that the hypernatremic condition may weaken local defence against risk factor for burn wound sepsis. (C) 1997 Elsevier Science Ltd for ISBI.
引用
收藏
页码:338 / 340
页数:3
相关论文
共 11 条
[1]  
BASS DA, 1983, J IMMUNOL, V130, P1910
[2]   ENERGY-METABOLISM OF HUMAN-NEUTROPHILS DURING PHAGOCYTOSIS [J].
BORREGAARD, N ;
HERLIN, T .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (03) :550-557
[3]  
DEMLING RH, 1987, SURG CLIN N AM, V67, P15
[4]  
DUNN PA, 1981, J LAB CLIN MED, V98, P374
[5]   Heat shock zone of the burn wound [J].
Harada, T ;
Kuroda, T ;
Tsutsumi, H ;
Kobayashi, M .
BURNS, 1996, 22 (07) :578-579
[6]   HYPERTONIC SODIUM RESUSCITATION IS ASSOCIATED WITH RENAL-FAILURE AND DEATH [J].
HUANG, PP ;
STUCKY, FS ;
DIMICK, AR ;
TREAT, RC ;
BESSEY, PQ ;
RUE, LW .
ANNALS OF SURGERY, 1995, 221 (05) :543-557
[7]  
JACKSON DM, 1952, BRIT J SURG, V40, P588
[8]   REGULATION OF CELLULAR VOLUME [J].
MACKNIGHT, ADC ;
LEAF, A .
PHYSIOLOGICAL REVIEWS, 1977, 57 (03) :510-573
[9]   SUPPRESSION OF LEUKOCYTE FUNCTION AND INTRACELLULAR CONTENT OF ATP IN HYPEROSMOTIC CONDITION COMPARABLE TO THE RENAL MEDULLA [J].
MATSUMOTO, T ;
KUMAZAWA, J ;
VANDERAUWERA, P .
JOURNAL OF UROLOGY, 1989, 142 (02) :399-402
[10]   SUPPRESSION OF CHEMOTACTIC ACTIVITY OF NEUTROPHILS IN HYPEROSMOTIC CONDITIONS COMPARABLE TO THE RENAL MEDULLA - PARTIAL PRESERVATION BY PHOSPHOENOLPYRUVATE [J].
MATSUMOTO, T ;
TAKAHASHI, K ;
KUBO, S ;
HARAOKA, M ;
MIZUNOE, Y ;
TANAKA, M ;
OGATA, N ;
NAITO, S ;
KUMAZAWA, J ;
WATANABE, Y .
UROLOGIA INTERNATIONALIS, 1993, 50 (01) :1-5