Synthesis and reactions of 1-(2-oxopropyl)pyridazin-6-ones

被引：8

作者：

Choi, WY ^{[1
]}

Cho, SD ^{[1
]}

Kim, SK ^{[1
]}

Yoon, YJ ^{[1
]}

机构：

[1] GYEONGSANG NATL UNIV,RES INST NAT SCI,CHINJU 660701,SOUTH KOREA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 04期

关键词：

D O I：

10.1002/jhet.5570340436

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxopropylation of 4,5-dihalopyridazin-6-ones with chloroacetone afforded the corresponding 1-(2-oxo-propyl) derivatives. Reaction of title compound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3-nitro-1-(2-oxopropyl)pyridazin-6-ones with iron/ammonium chloride in two phase solutions or zinc in acetic acid gave the corresponding 3-amino or 3-hydroxyimino derivatives.

引用

页码：1307 / 1313

页数：7

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