Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)

被引：62

作者：

Cross, Janet V. ^{[1
]}

Rady, Joshua M. ^{[1
]}

Foss, Frank W., Jr. ^{[2
]}

Lyons, Charles E. ^{[1
]}

MacDonald, Timothy L. ^{[2
]}

Templeton, Dennis J. ^{[1
]}

机构：

[1] Univ Virginia, Dept Pathol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Chem, Charlottesville, VA 22908 USA

来源：

BIOCHEMICAL JOURNAL | 2009年 / 423卷

基金：

美国国家卫生研究院;

关键词：

cancer; cytokine; inflammation; isothiocyanate (ITC); macrophage migration inhibitory factor (MIF); tautomerase; CELL LUNG-CANCER; TUMOR-GROWTH; IN-VIVO; EXPRESSION; VITRO; MICE; HYPERSENSITIVITY; SITE;

D O I：

10.1042/BJ20091170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Dietary ITCs (isothiocyanates) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified MIF (macrophage migration inhibitory factor) as the principal target of nutrient ITCs in intact cells. ITCs covalently modify the N-terminal proline residue of MIF and extinguish its catalytic tautomerase activity. MIF deficiency does not prevent induction of Phase 2 gene expression, a hallmark of many cancer chemopreventives, including ITCs. Due to the emerging role of MIF in the control of malignant cell growth and its clear involvement in inflammation, inhibition of MIF by nutrient ITCs suggests therapeutic strategies for inflammatory diseases and cancer.

引用

页码：315 / 321

页数：7

共 23 条

[1]

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis [J].

Al-Abed, Y ;

Dabideen, D ;

Aljabari, B ;

Valster, A ;

Messmer, D ;

Ochani, M ;

Tanovic, M ;

Ochani, K ;

Bacher, M ;

Nicoletti, F ;

Metz, C ;

Pavlov, VA ;

Miller, EJ ;

Tracey, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (44) :36541-36544

[2]

Expression of macrophage migration inhibitory factor in human breast cancer: Association with nodal spread [J].

Bando, H ;

Matsumoto, G ;

Bando, M ;

Muta, M ;

Ogawa, T ;

Funata, N ;

Nishihira, J ;

Koike, M ;

Toi, M .

JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (04) :389-396

[3]

MECHANISM OF A REACTION IN VITRO ASSOCIATED WITH DELAYED-TYPE HYPERSENSITIVITY [J].

BLOOM, BR ;

BENNETT, B .

SCIENCE, 1966, 153 (3731) :80-&

[4]

Campa MJ, 2003, CANCER RES, V63, P1652

[5]

Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase [J].

Chen, YR ;

Han, J ;

Kori, R ;

Kong, ANT ;

Tan, TH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39334-39342

[6]

Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes [J].

Cvetkovic, I ;

Al-Abed, Y ;

Miljkovic, D ;

Maksimovic-Ivanic, D ;

Roth, J ;

Bacher, M ;

Lan, HY ;

Nicoletti, F ;

Stosic-Grujicic, S .

ENDOCRINOLOGY, 2005, 146 (07) :2942-2951

[7]

DELAYED HYPERSENSITIVITY IN VITRO - ITS MEDIATION BY CELL-FREE SUBSTANCES FORMED BY LYMPHOID CELL-ANTIGEN INTERACTION [J].

DAVID, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (01) :72-&

[8]

Development of chronic colitis is dependent on the cytokine MIF [J].

de Jong, YP ;

Abadia-Molina, AC ;

Satoskar, AR ;

Clarke, K ;

Rietdijk, ST ;

Faubion, WA ;

Mizoguchi, E ;

Metz, CN ;

Al Sahli, M ;

ten Hove, T ;

Keates, AC ;

Lubetsky, JB ;

Farrell, RJ ;

Michetti, P ;

van Deventer, SJ ;

Lolis, E ;

David, JR ;

Bhan, AK ;

Terhorst, C .

NATURE IMMUNOLOGY, 2001, 2 (11) :1061-1066

[9]

Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis [J].

Hagemann, Thorsten ;

Robinson, Stephen C. ;

Thompson, Richard G. ;

Charles, Kellie ;

Kulbe, Hagen ;

Balkwill, Frances R. .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (07) :1993-2002

[10]

Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination [J].

Hecht, SS ;

Upadhyaya, P ;

Wang, M ;

Bliss, RL ;

McIntee, EJ ;

Kenney, PMJ .

CARCINOGENESIS, 2002, 23 (09) :1455-1461

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