Simultaneous quantitative analysis of FcγRI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases

被引：56

作者：

Jalava-Karvinen, Paivi ^{[2
]}

Hohenthal, Ulla ^{[2
]}

Laitinen, Iina ^{[1
]}

Kotilainen, Pirkko ^{[2
]}

Rajamaki, Allan ^{[3
]}

Nikoskelainen, Jukka ^{[2
]}

Lilius, Esa-Matti ^{[1
]}

Nuutila, Jari ^{[1
]}

机构：

[1] Univ Turku, Dept Biochem, Turku 20014, Finland

[2] Turku Univ, Cent Hosp, Dept Med, Turku, Finland

[3] Hosp Mehilainen, Turku, Finland

来源：

CLINICAL IMMUNOLOGY | 2009年 / 133卷 / 03期

关键词：

Infectious diseases; Inflammatory diseases; Differential diagnosis; Neutrophil CD64; Neutrophil CD35; Bacterial infections; Viral infections; ONSET STILLS-DISEASE; SYNOVIAL-FLUID; EXPRESSION; MOLECULES; MARKERS; BLOOD;

D O I：

10.1016/j.clim.2009.08.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A flow cytometric quantitative analysis of receptors on neutrophils can be exploited in distinguishing between inflammatory and infectious diseases. In this prospective comparative study, simultaneous quantitative analysis of CD64 and CD35 on peripheral blood neutrophils was performed in febrile patients in order to differentiate between bacterial infections (n=89), viral infections (n=46), and inflammatory diseases (n=21). The patient data was compared to 60 healthy controls. We could divide patients into three groups depending on how they express CD35 and CD64 on neutrophils: (1) patients with a high probability of viral infection (tow CD35/low CD64 and low CD35/high CD64), (2) patients with a high probability of inflammatory disease (high CD35/low CD64), and (3) patients with a high probability of bacterial infection (high CD35/high CD64). In summary, simultaneous quantitative analysis of CD64 and CD35 on neutrophils could potentially assist physicians to distinguish between inflammatory and infectious diseases. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：314 / 323

页数：10

共 21 条

[1]

Neutrophil CD64 expression: distinguishing acute inflammatory autoimmune disease from systemic infections [J].