An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform

被引：494

作者：

Bagalkot, Vaishali

Farokhzad, Omid C.

Langer, Robert

Jon, Sangyong

机构：

[1] Brigham & Womens Hosp, Dept Anaesthesiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 48期

关键词：

antitumor agents; aptamers; conjugation; drug delivery; targeted therapy;

D O I：

10.1002/anie.200602251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trojan aptamer: A novel strategy for targeted drug delivery to cancer cells was developed through the formation of a physical conjugate (see scheme) between doxorubicin (Dox) and the A10 RNA aptamer that binds to the prostate-specific membrane antigen (PSMA). The aptamer-Dox conjugate could efficiently bind to PSMA-expressing cells, thereby resulting in its uptake and the intracellular release of Dox. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

页码：8149 / 8152

页数：4

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