Translational medicine: the antihypertensive effect of renal denervation

被引：303

作者：

DiBona, Gerald F. ^{[1
,2
]}

Esler, Murray ^{[3
]}

机构：

[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

[2] Vet Adm Med Ctr, Iowa City, IA USA

[3] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2010年 / 298卷 / 02期

关键词：

SYMPATHETIC-NERVOUS-SYSTEM; ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; INNERVATION; AFFERENT; OBESITY; MUSCLE; RESPONSES; OVERFLOW; STRESS;

D O I：

10.1152/ajpregu.00647.2009

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

DiBona GF, Esler M. Translational medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol 298: R245-R253, 2010. First published December 2, 2009; doi:10.1152/ajpregu.00647.2009.- Translational medicine is concerned with the translation of research discoveries into clinical applications for the prevention, diagnosis, and treatment of human diseases. Here we briefly review the research concerning the role of the renal sympathetic nerves (efferent and afferent) in the control of renal function, with particular reference to hypertension. The accumulated evidence is compelling for a primary role of the renal innervation in the pathogenesis of hypertension. These research discoveries led to the development of a catheter-based procedure for renal denervation in human subjects. A proof-of-principle study in patients with hypertension resistant to conventional therapy has demonstrated that the procedure is safe and produces renal denervation with sustained lowering of arterial pressure.

引用

页码：R245 / R253

页数：9

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