Caspase inhibitors: viral, cellular and chemical

被引：146

作者：

Callus, B. A. ^{[1
]}

Vaux, D. L. ^{[1
]}

机构：

[1] La Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia

来源：

CELL DEATH AND DIFFERENTIATION | 2007年 / 14卷 / 01期

基金：

英国医学研究理事会;

关键词：

caspase; IAP; apoptosis; protease; p35;

D O I：

10.1038/sj.cdd.4402034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases, key mediators of apoptosis, are a structurally related family of cysteine proteases that cleave their substrates at aspartic acid residues either to cause cell death or to activate cytokines as part of an immune response. They can be controlled upstream by the regulation of signals that lead to zymogen activation, or downstream by inhibitors that prevent them from reaching their substrates. This review specifically looks at caspase inhibitors as distinct from caspase regulators: those produced by the cell itself; those whose genes are carried by viruses; and artificial caspase inhibitors used for research and potentially as therapeutics.

引用

页码：73 / 78

页数：6

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