Neonatal Cholestasis

被引：51

作者：

Lane, Erin ^{[1
]}

Murray, Karen F. ^{[1
]}

机构：

[1] Seattle Childrens Hosp, Div Gastroenterol, 4800 Sand Point Way Northeast,M-S OB 9-620, Seattle, WA 98115 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2017年 / 64卷 / 03期

关键词：

Neonatal cholestasis; Neonatal liver disease; Biliary atresia; Jaundice; Cholestasis; TYROSINEMIA TYPE-I; BILIARY ATRESIA; ALAGILLE-SYNDROME; LIVER-DISEASE; CHOLEDOCHAL CYSTS; NOTCH2; MUTATIONS; RISK-FACTORS; HEPATITIS; CARCINOMA; FREQUENCY;

D O I：

10.1016/j.pcl.2017.01.006

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Neonatal jaundice is common and usually not concerning when it is secondary to unconjugated hyperbilirubinemia, below the neurotoxic level, and resolves early. Primary care providers should be vigilant, however, about evaluating infants in whom jaundice presents early, is prolonged beyond 2 weeks of life, or presents at high levels. Even in well-appearing infants, fractionated (direct and indirect) bilirubin levels should be obtained in these clinical scenarios to evaluate for potential cholestasis. This review presents an approach to the evaluation of a jaundiced infant and discusses diagnosis and management of several causes of neonatal cholestasis.

引用

页码：621 / +

页数：20

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