Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin

被引:415
作者
Adameyko, Igor [1 ]
Lallemend, Francois [1 ]
Aquino, Jorge B. [1 ,2 ]
Pereira, Jorge A. [3 ]
Topilko, Piotr [4 ]
Mueller, Thomas [5 ]
Fritz, Nicolas [1 ]
Beljajeva, Anna [6 ]
Mochii, Makoto [7 ]
Liste, Isabel [1 ]
Usoskin, Dmitry [1 ]
Suter, Ueli [3 ]
Birchmeier, Carmen [5 ]
Ernfors, Patrik [1 ]
机构
[1] Karolinska Inst, Dept Med Biochem & Biophys, Mol Neurobiol Unit, S-17177 Stockholm, Sweden
[2] Austral Univ, Sch Med, Liver Unit, Buenos Aires, DF, Argentina
[3] ETH, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland
[4] Ecole Normale Super, Inserm 784, Lab Genet Mol Dev, F-75230 Paris 05, France
[5] Max Delbruck Ctr Mol Med, Dept Neurosci, D-13125 Berlin, Germany
[6] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
[7] Univ Hyogo, Grad Sch Life Sci, Dept Life Sci, Akoh, Hyogo 6781297, Japan
基金
瑞士国家科学基金会; 瑞典研究理事会;
关键词
NEURAL CREST CELLS; LINEAGE SEGREGATION; GROWTH-FACTOR; MOUSE EMBRYO; GLIAL-CELLS; EXPRESSION; MIGRATION; DIFFERENTIATION; MELANOBLASTS; SYSTEM;
D O I
10.1016/j.cell.2009.07.049
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin. Here, we identify growing nerves projecting throughout the body as a stem/progenitor niche containing Schwann cell precursors (SCPs) from which large numbers of skin melanocytes originate. SCPs arise as a result of lack of neuronal specification by Hmx1 homeobox gene function in the neural crest ventral migratory pathway. Schwann cell and melanocyte development share signaling molecules with both the glial and melanocyte cell fates intimately linked to nerve contact and regulated in an opposing manner by Neuregulin and soluble signals including insulin-like growth factor and platelet-derived growth factor. These results reveal SCPs as a cellular origin of melanocytes, and have broad implications on the molecular mechanisms regulating skin pigmentation during development, in health and pigmentation disorders.
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页码:366 / 379
页数:14
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