A simple convergent synthesis of trans-fused six-membered polycyclic ethers

被引：33

作者：

Mori, Y ^{[1
]}

Mitsuoka, S ^{[1
]}

Furukawa, H ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 468, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 21期

关键词：

alkynes; acetals; polyethers; reduction; tetrahydropyrans;

D O I：

10.1016/S0040-4039(00)00558-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly convergent method for the synthesis of trans-fused polytetrahydropyrans was developed, which involves: (i) coupling of cyclic triflate with an acetylene unit; (ii) oxidation of acetylene to 1,2-diketone; (iii) formation of a trans-fused cyclic dihemiacetal; (iv) O-methylation of the dihemiacetal; and (v) stereoselective reduction of the diacetal to trans-fused oxane rings. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4161 / 4164

页数：4

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