Transcriptional regulation of cellular transformation

被引:18
作者
Salomoni, P
Pandolfi, PP
机构
[1] Cornell Univ, Grad Sch Med Sci, Sloan Kettering Div,Dept Human Genet, Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[2] Cornell Univ, Grad Sch Med Sci, Sloan Kettering Div,Mol Biol Program, Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
关键词
D O I
10.1038/77459
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Structurally and functionally altered transcription factors have been associated with many human neoplasms. A better understanding of these transcriptional defects has revealed new therapeutic opportunities.
引用
收藏
页码:742 / 744
页数:3
相关论文
共 15 条
[1]   A decade of molecular biology of retinoic acid receptors [J].
Chambon, P .
FASEB JOURNAL, 1996, 10 (09) :940-954
[2]   THE PML-RAR-ALPHA FUSION MESSENGER-RNA GENERATED BY THE T(15-17) TRANSLOCATION IN ACUTE PROMYELOCYTIC LEUKEMIA ENCODES A FUNCTIONALLY ALTERED RAR [J].
DETHE, H ;
LAVAU, C ;
MARCHIO, A ;
CHOMIENNE, C ;
DEGOS, L ;
DEJEAN, A .
CELL, 1991, 66 (04) :675-684
[3]   Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia [J].
Grignani, F ;
De Matteis, S ;
Nervi, C ;
Tomassoni, L ;
Gelmetti, V ;
Cioce, M ;
Fanelli, M ;
Ruthardt, M ;
Ferrara, FF ;
Zamir, I ;
Seiser, C ;
Grignani, F ;
Lazar, MA ;
Minucci, S ;
Pelicci, PG .
NATURE, 1998, 391 (6669) :815-818
[4]   THE ACUTE PROMYELOCYTIC LEUKEMIA-SPECIFIC PML-RAR-ALPHA FUSION PROTEIN INHIBITS DIFFERENTIATION AND PROMOTES SURVIVAL OF MYELOID PRECURSOR CELLS [J].
GRIGNANI, F ;
FERRUCCI, PF ;
TESTA, U ;
TALAMO, G ;
FAGIOLI, M ;
ALCALAY, M ;
MENCARELLI, A ;
GRIGNANI, F ;
PESCHLE, C ;
NICOLETTI, I ;
PELICCI, PG .
CELL, 1993, 74 (03) :423-431
[5]   In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications [J].
He, LZ ;
Merghoub, T ;
Pandolfi, PP .
ONCOGENE, 1999, 18 (38) :5278-5292
[6]   Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL [J].
He, LZ ;
Guidez, F ;
Tribioli, C ;
Peruzzi, D ;
Ruthardt, M ;
Zelent, A ;
Pandolfi, PP .
NATURE GENETICS, 1998, 18 (02) :126-135
[7]   CHROMOSOMAL TRANSLOCATION T(15-17) IN HUMAN ACUTE PROMYELOCYTIC LEUKEMIA FUSES RAR-ALPHA WITH A NOVEL PUTATIVE TRANSCRIPTION FACTOR, PML [J].
KAKIZUKA, A ;
MILLER, WH ;
UMESONO, K ;
WARRELL, RP ;
FRANKEL, SR ;
MURTY, VVVS ;
DMITROVSKY, E ;
EVANS, RM .
CELL, 1991, 66 (04) :663-674
[8]   Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers [J].
Lin, RJ ;
Evans, RM .
MOLECULAR CELL, 2000, 5 (05) :821-830
[9]   Role of the histone deacetylase complex in acute promyelocytic leukaemia [J].
Lin, RJ ;
Nagy, L ;
Inoue, S ;
Shao, WL ;
Miller, WH ;
Evans, RM .
NATURE, 1998, 391 (6669) :811-814
[10]   Oncogenic transcription factors in the human acute leukemias [J].
Look, AT .
SCIENCE, 1997, 278 (5340) :1059-1064