Melatonin synthesis:: A possible indicator of intolerance to shiftwork

被引:24
作者
Griefahn, B
Künemund, C
Golka, K
Thier, R
Degen, G
机构
[1] Univ Dortmund, Inst Occupat Physiol, D-44139 Dortmund, Germany
[2] Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld, Australia
关键词
salivary melatonin concentrations; rectal temperature; diurnal type; shift work; constant routine;
D O I
10.1002/ajim.10122
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Hypothesis Melatonin synthesis, which is directly controlled by the central circadian pacemaker indicates the circadian phase better than rectal temperature. Methods Thirty four men (16-32 years, 7 morning, 13 neither, 14 evening types) performed a constant routine (24-26-hr bedrest, <30 lux, 18-20degreesC, hourly isocaloric diet). Salivary melatonin level was determined hourly and rectal temperature was continuously recorded. Results The nadir of rectal temperature occurred 1.5 hr (P = 0.017), the onset of melatonin synthesis 3 hr earlier (P < 0.0001) in morning than in evening types. Morningness was not related to the quantitative but significantly to the temporal parameters, closer to those of melatonin than of rectal temperature. Conclusions The melatonin onset is a more reliable indicator of the diurnal type than the nadir of rectal temperature. As morningness has been associated with intolerance to shiftwork, melatonin profiling provides a suitable basis for the establishment of directed preventive measures. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:427 / 436
页数:10
相关论文
共 39 条
[1]  
AKERSTEDT T, 2000, P NATO 99 HFM WORKSH
[2]   Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology [J].
Arendt, J .
REVIEWS OF REPRODUCTION, 1998, 3 (01) :13-22
[3]   THE IMPACT OF NIGHT WORK ON PSYCHOLOGICAL WELL-BEING [J].
BOHLE, P ;
TILLEY, AJ .
ERGONOMICS, 1989, 32 (09) :1089-1099
[4]   THE STATISTICAL-ANALYSIS OF CIRCADIAN PHASE AND AMPLITUDE IN CONSTANT-ROUTINE CORE-TEMPERATURE DATA [J].
BROWN, EN ;
CZEISLER, CA .
JOURNAL OF BIOLOGICAL RHYTHMS, 1992, 7 (03) :177-202
[5]   A mathematical model of diurnal variations in human plasma melatonin levels [J].
Brown, EN ;
Choe, Y ;
Shanahan, TL ;
Czeisler, CA .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 272 (03) :E506-E516
[6]   Influences of melatonin on human circadian rhythms [J].
Cagnacci, A .
CHRONOBIOLOGY INTERNATIONAL, 1997, 14 (02) :205-220
[7]   CIRCADIAN CHARACTERISTICS INFLUENCING INTERINDIVIDUAL DIFFERENCES IN TOLERANCE AND ADJUSTMENT TO SHIFTWORK [J].
COSTA, G ;
LIEVORE, F ;
CASALETTI, G ;
GAFFURI, E ;
FOLKARD, S .
ERGONOMICS, 1989, 32 (04) :373-385
[8]  
Czeisler C.A, 1985, Sleep Research, V14, P295
[9]   The hypothermic effect of melatonin on core body temperature: Is more better? [J].
Dawson, D ;
Gibbon, S ;
Singh, P .
JOURNAL OF PINEAL RESEARCH, 1996, 20 (04) :192-197
[10]  
DEACON S, 1994, NEUROSCI LETT, V167, P1910