Receptor recognition by gp130 cytokines

被引:165
作者
Bravo, J
Heath, JK [1 ]
机构
[1] Univ Birmingham, CRC, Growth Factor Grp, Sch Biosci, Birmingham B15 2TT, W Midlands, England
[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
cytokines; gp130; receptor recognition epitopes; receptor signalling complexes;
D O I
10.1093/emboj/19.11.2399
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three-dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.
引用
收藏
页码:2399 / 2411
页数:13
相关论文
共 119 条
  • [1] Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme
    Aritomi, M
    Kunishima, N
    Okamoto, T
    Kuroki, R
    Ota, Y
    Morikawa, K
    [J]. NATURE, 1999, 401 (6754) : 713 - 718
  • [2] Will any dimer do?
    Ballinger, MD
    Wells, JA
    [J]. NATURE STRUCTURAL BIOLOGY, 1998, 5 (11) : 938 - 940
  • [3] Identification of three distinct receptor binding sites of murine interleukin-11
    Barton, VA
    Hudson, KR
    Heath, JK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (09) : 5755 - 5761
  • [4] NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD
    BAZAN, JF
    [J]. NEURON, 1991, 7 (02) : 197 - 208
  • [6] Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects
    Betz, UAK
    Bloch, W
    van den Broek, M
    Yoshida, K
    Taga, T
    Kishimoto, T
    Addicks, K
    Rajewsky, K
    Müller, W
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (10) : 1955 - 1965
  • [7] Maternal IL-11Rα function is required for normal decidua and fetoplacental development in mice
    Bilinski, P
    Roopenian, D
    Gossler, A
    [J]. GENES & DEVELOPMENT, 1998, 12 (14) : 2234 - 2243
  • [8] HEMATOPOIETIN SUBFAMILY CLASSIFICATION BASED ON SIZE, GENE ORGANIZATION AND SEQUENCE HOMOLOGY
    BOULAY, JL
    PAUL, WE
    [J]. CURRENT BIOLOGY, 1993, 3 (09) : 573 - 581
  • [9] BRAKENHOFF JPJ, 1994, J BIOL CHEM, V269, P86
  • [10] Crystal structure of a cytokine-binding region of gp130
    Bravo, J
    Staunton, D
    Heath, JK
    Jones, EY
    [J]. EMBO JOURNAL, 1998, 17 (06) : 1665 - 1674