Differences in skin-prick and patch-test reactivity are related to the heterogeneity of atopic eczema in infants

被引:58
作者
Kekki, OM
Turjanmaa, K
Isolauri, E
机构
[1] UNIV TURKU, DEPT PAEDIAT, SF-20500 TURKU, FINLAND
[2] UNIV TAMPERE, FIN-33101 TAMPERE, FINLAND
关键词
atopic eczema; food allergy; food challenge; patch test;
D O I
10.1111/j.1398-9995.1997.tb01234.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Current data indicate an obvious relation between food allergy and atopic eczema in infants. However, diagnostic methods for food allergy need to be supplemented. The objective was to study the relevance of food patch testing in the detection of food allergy in correlation with oral food challenge and skin prick tests in atopic infants. Infants with atopic eczema (n=113) aged 2-24 months were studied. Each patient was subjected to double-blind, placebo-controlled, or open cow's milk challenge, and skin prick and patch tests. Polysensitization, as judged from skin test results, was common in patients with atopic eczema (79/113). Cow's milk challenge was positive in 54/113 infants; reactions were immediate in 36/54 and delayed in 18/54. Immediate-type reactions were associated with skin prick test positivity and delayed reactions with patch test positivity. Altogether 26% of the cow's milk-allergic infants were detected by patch testing only. Patch testing improved the accuracy of skin testing in the diagnosis of food allergy in infants with atopic eczema, but it needs to be standardized. Polysensitization appears to be more common than generally believed among infants with atopic eczema.
引用
收藏
页码:755 / 759
页数:5
相关论文
共 19 条
[1]   EFFECT OF ELIMINATION DIETS ON FOOD-SPECIFIC IGE ANTIBODIES AND LYMPHOCYTE PROLIFERATIVE RESPONSES TO FOOD ANTIGENS IN ATOPIC-DERMATITIS PATIENTS EXHIBITING SENSITIVITY TO FOOD ALLERGENS [J].
AGATA, H ;
KONDO, N ;
FUKUTOMI, O ;
SHINODA, S ;
ORII, T .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1993, 91 (02) :668-679
[2]   NATURAL-HISTORY OF COW MILK ALLERGY - CLINICAL OUTCOME [J].
BISHOP, JM ;
HILL, DJ ;
HOSKING, CS .
JOURNAL OF PEDIATRICS, 1990, 116 (06) :862-867
[3]   PATTERNS OF FOOD HYPERSENSITIVITY DURING 16 YEARS OF DOUBLE-BLIND, PLACEBO-CONTROLLED FOOD CHALLENGES [J].
BOCK, SA ;
ATKINS, FM .
JOURNAL OF PEDIATRICS, 1990, 117 (04) :561-567
[4]  
BORKOWSKI TA, 1996, DERMATOL THER, V1, P38
[5]   ATOPIC-DERMATITIS - CLINICAL RELEVANCE OF FOOD HYPERSENSITIVITY REACTIONS [J].
BURKS, AW ;
MALLORY, SB ;
WILLIAMS, LW ;
SHIRRELL, MA .
JOURNAL OF PEDIATRICS, 1988, 113 (03) :447-451
[6]   ATOPY PATCH TEST WITH DIFFERENT VEHICLES AND ALLERGEN CONCENTRATIONS - AN APPROACH TO STANDARDIZATION [J].
DARSOW, U ;
VIELUF, D ;
RING, J .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 95 (03) :677-684
[7]   ANALYSIS OF THE CYTOKINE PATTERN EXPRESSED IN-SITU IN INHALANT ALLERGEN PATCH TEST REACTIONS OF ATOPIC-DERMATITIS PATIENTS [J].
GREWE, M ;
WALTHER, S ;
GYUFKO, K ;
CZECH, W ;
SCHOPF, E ;
KRUTMANN, J .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (03) :407-410
[8]  
Hanifin JM., 1980, Acta Dermatovener (Stockholm) Suppl, V60, P42
[9]   Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis [J].
Isolauri, E ;
Turjanmaa, K .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1996, 97 (01) :9-15
[10]   THE ROLE OF LYMPHOCYTES-T IN PATIENTS WITH FOOD-SENSITIVE ATOPIC-DERMATITIS [J].
KONDO, N ;
FUKUTOMI, O ;
AGATA, H ;
MOTOYOSHI, F ;
SHINODA, S ;
KOBAYASHI, Y ;
KUWABARA, N ;
KAMEYAMA, T ;
ORII, T .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1993, 91 (02) :658-668