The discovery and development of P2 receptor subtypes

被引:24
作者
Kennedy, C [1 ]
机构
[1] Univ Strathclyde, Inst Biomed Res, Dept Physiol & Pharmacol, Glasgow G4 0NR, Lanark, Scotland
来源
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 2000年 / 81卷 / 1-3期
关键词
P2; receptors; P2X receptors; P2Y receptors;
D O I
10.1016/S0165-1838(00)00133-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Extracellular purine and pyrimidine nucleotides modulate cellular activity by acting at P2, receptors. The first receptor to be identified was the P-2-purinoceptor, which was characterised and named in 1978. In the 1980s this site was subdivided into P-2X and P-2Y purinoceptors on the basis of pharmacological criteria in functional studies on native receptors. Subsequently, a similar approach led to the characterisation of the P-2T, P-2Z, P-2U and P-2D purinoceptors. In the 1990s a molecular biological approach has led to the cloning and functional expression of at least 12 mammalian P2 receptor subtypes. The challenge now is to relate these recombinant receptors to native receptors present within a wide range of tissues. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:158 / 163
页数:6
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