Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

被引：124

作者：

Mazure, Nathalie M. ^{[1
]}

Pouyssegur, Jacques ^{[1
]}

机构：

[1] CNRS, UMR 6543, Inst Canc & Dev Biol, F-06189 Nice, Paca, France

来源：

AUTOPHAGY | 2009年 / 5卷 / 06期

关键词：

autophagy; BNIP3; BNIP3L; atypical BH3-domain; cancer; hypoxia;

D O I：

10.4161/auto.9042

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Normal and tumor cells subjected to a hypoxic microenvironment show evidence of autophagy. We hypothesize that cells will sense hypoxia as a warning signal to upcoming drastic microenvironmental conditions and that autophagy, acting as a survival mechanism, will provide time for cells to adapt. This work demonstrates for the first time that the atypical BH3-domain of BNIP3 and BNIP3L, two HIF-target genes, can compete with Beclin 1-Bcl-2 and Beclin 1-Bcl-X-L Complexes' releasing Beclin I from the complex and then enhancing autophagy. We thus revealed a new role for BH3-only proteins in the cellular response to hypoxia.

引用

页码：868 / 869

页数：2