Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials

被引：102

作者：

Kosmala, JD ^{[1
]}

Henthorn, DB ^{[1
]}

Brannon-Peppas, L ^{[1
]}

机构：

[1] Biogel Technol Inc, Indianapolis, IN 46268 USA

来源：

BIOMATERIALS | 2000年 / 21卷 / 20期

关键词：

hydrogels; gelatin; dextran; glyceraldehyde;

D O I：

10.1016/S0142-9612(00)00057-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Gelatin and dextran were blended and crosslinked to form enzymatically degradable interpenetrating polymeric networks (IPNs) as materials for degradable implants. Several crosslinking methods were investigated including treatment with glyceraldehyde, thermal hardening, and chelation of dextran by divalent metal cations. IPNs were characterized by an equilibrium swelling method. Gelatin/dextran IPNs were stable at 25 degrees C and reached peak volume equilibrium swelling ratios up to 17 and peak weight swelling ratios up to 15. When swollen at 37 degrees C, the gels dissolved denoting that a network had been formed by physical and not chemical crosslinks. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2019 / 2023

页数：5

共 17 条

[1] DYNAMIC AND EQUILIBRIUM SWELLING BEHAVIOR OF PH-SENSITIVE HYDROGELS CONTAINING 2-HYDROXYETHYL METHACRYLATE
BRANNONPEPPAS, L
PEPPAS, NA
[J]. BIOMATERIALS, 1990, 11 (09) : 635 - 644
[2] Crosslinked dextran - a new capsule material for colon targeting of drugs
Brondsted, H
Andersen, C
Hovgaard, L
[J]. JOURNAL OF CONTROLLED RELEASE, 1998, 53 (1-3) : 7 - 13
[3] Dextran cross-linked gelatin microspheres as a drug delivery system
Cortesi, R
Esposito, E
Osti, M
Squarzoni, G
Menegatti, E
Davis, SS
Nastruzzi, C
[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1999, 47 (02) : 153 - 160
[4] de Raucourt E, 1998, J BIOMED MATER RES, V41, P49, DOI 10.1002/(SICI)1097-4636(199807)41:1<49::AID-JBM6>3.0.CO
[5] 2-Q
[6] In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films
Draye, JP
Delaey, B
Van de Voorde, A
Van Den Bulcke, A
Bogdanov, B
Schacht, E
[J]. BIOMATERIALS, 1998, 19 (1-3) : 99 - 107
[7] Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties
Esposito, E
Cortesi, R
Nastruzzi, C
[J]. BIOMATERIALS, 1996, 17 (20) : 2009 - 2020
[8] KURISAWA M, 1997, P INT S CONTR REL BI, V24, P579
[9] Biological effects and cytotoxicity of the composite composed by tricalcium phosphate and glutaraldehyde cross-linked gelatin
Lin, FH
Yao, CH
Sun, JS
Liu, HC
Huang, CW
[J]. BIOMATERIALS, 1998, 19 (10) : 905 - 917
[10] Park H., 1993, Biodegradable Hydrogels for Drug Delivery

← 1 2 →