Near-Infrared Fluorescent NanoGUMBOS for Biomedical Imaging

被引：81

作者：

Bwambok, David K. ^{[1
]}

El-Zahab, Bilal ^{[1
]}

Challa, Santhosh K. ^{[1
]}

Li, Min ^{[1
]}

Chandler, Lin ^{[2
]}

Baker, Gary A. ^{[3
]}

Warner, Isiah M. ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[2] Horiba Jobin Yvon Inc, Edison, NJ 08820 USA

[3] Oak Ridge Natl Lab, Div Chem Sci, Oak Ridge, TN 37831 USA

来源：

ACS NANO | 2009年 / 3卷 / 12期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

near-infrared; fluorescence; ionic liquids; GUMBOS; nanoparticles; nanoGUMBOS; biomedical imaging; DESIGNING IONIC LIQUIDS; INDOCYANINE-GREEN; PHOTODYNAMIC THERAPY; TUNABLE EMISSION; NANOPARTICLES; WATER; LIGHT; DYE;

D O I：

10.1021/nn9010126

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report on near-infrared (NIR) fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are largely frozen ionic liquids, although the concept is more general and is also easily applied to solid ionic materials with melting points in excess of 100 degrees C. Nanoparticles based on GUMBOS (nanoGUMBOS) derived from a NIR fluorophore are prepared using a reprecipitation method and evaluated for in vivo fluorescence imaging. Due to their uniformity, single-step preparation, and composite nature, nanoGUMBOS help to resolve issues with dye leakage problems innate to alternate cellular stains and unlock a myriad of applications for these materials, highlighting exciting possibilities for multifunctional nanoGUMBOS.

引用

页码：3854 / 3860

页数：7

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