Chaperoning Histones during DNA Replication and Repair

被引:279
作者
Ransom, Monica [1 ]
Dennehey, Briana K. [1 ]
Tyler, Jessica K. [1 ]
机构
[1] Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA
关键词
CHROMATIN ASSEMBLY FACTOR-1; DOUBLE-STRAND BREAK; H3; LYSINE-56; ACETYLATION; FISSION YEAST SCM3; CENP-A; SACCHAROMYCES-CEREVISIAE; HUMAN-CELLS; IN-VIVO; STRUCTURAL BASIS; S-PHASE;
D O I
10.1016/j.cell.2010.01.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair. © 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:183 / 195
页数:13
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