syn-selective and enantioselective direct cross-aldol reactions between aldehydes catalyzed by an axially chiral amino sulfonamide

被引：122

作者：

Kano, Taichi ^{[1
]}

Yamaguchi, Yukako ^{[1
]}

Tanaka, Youhei ^{[1
]}

Maruoka, Keiji ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 10期

关键词：

aldol reaction; asymmetric catalysis; diastereoselectivity; enantioselectivity; synthetic methods;

D O I：

10.1002/anie.200604640

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Complementary to proline: An axially chiral amino sulfonamide (S)-1 was successfully applied as the catalyst to the direct cross-aldol reaction between two different aldehydes (see scheme; NMP = N-methylpyrrolidone). This catalyst has the advantage of giving mainly syn products, while proline shows the opposite anti selectivity. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1738 / 1740

页数：3

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