The non-human primate model of endometriosis: research and implications for fecundity

被引：72

作者：

Braundmeier, A. G. ^{[1
]}

Fazleabas, A. T. ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Obstet & Gynecol MC808, Chicago, IL 60612 USA

来源：

MOLECULAR HUMAN REPRODUCTION | 2009年 / 15卷 / 10期

基金：

美国国家卫生研究院;

关键词：

animal model; endometriosis; endometrium; primate; uterine; pathologies; ACTIVATED RECEPTOR-GAMMA; ENDOTHELIAL GROWTH-FACTOR; DNA MICROARRAY ANALYSIS; STEROIDOGENIC-FACTOR-I; MATRIX-METALLOPROTEINASE EXPRESSION; BABOON PAPIO-ANUBIS; NF-KAPPA-B; GENE-EXPRESSION; PROGESTERONE RESISTANCE; AROMATASE EXPRESSION;

D O I：

10.1093/molehr/gap057

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).

引用

页码：577 / 586

页数：10

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