Does Single-dose Preoperative Dexamethasone Minimize Stress Response and Improve Recovery After Laparoscopic Cholecystectomy?

Background: Stress response after laparoscopic cholecystectomy (LC) is less compared with open cholecystectomy, but is still responsible for significant postoperative morbidity. Though preoperative glucocorticoids were found to be effective in reducing the response in open surgical procedures, their role in minimal access surgery is not clear. Aims and Objectives: To evaluate the efficacy of single-dose preoperative dexamethasone in reducing the stress response and postoperative morbidity after LC. Materials and Methods: In a prospective randomized; double-blind, placebo-controlled trial, 70 patients undergoing elective LC were randomized to receive either dexamethasone (8 mg intravenously); or placebo. The change in C-reactive protein levels after LC, pain scores at rest. and on exertion and narcotic requirements, the incidence and severity of postoperative nausea and vomiting (PONY), anti-emetic requirement, peak expiratory flow rate in both groups were compared. Results: Dexamethasone was more effective in controlling late PONY (P = 0.05). The antiemetic requirement was significantly less in the dexamethasone group (0.56 mg vs. 2.24 mg; P = 0.02). Median pain scores were significantly less in the dexamethasone group at 24 hours at rest (P = 0.002) and on exertion at 24 and 48 hours (P = 0.03 and 0.001). Analgesic requirement was less in the test group (22.9 mg vs. 29.9 mg; P = 0.054). The peak expiratory flow rate at 48 hours was higher in the dexamethasone group (315.28 vs. 285.8 1/min; P = 0.04). The dexamethasone group showed significantly less elevation of C-reactive protein levels at 24 hours (7.17 mu g/mL vs. 17.53 mu g/mL; P = 0.003) and 48 hours (10.65 mu g/mL vs. 23.18 mu g/mL; P = 0.02) postoperatively. Conclusions: Preoperative single-dose dexamethasone significantly reduces the pain scores, PONV, and antiemetic requirements while improving the respiratory function in the postoperative period after LC.