Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

被引：7

作者：

Rubal, Juan J.

Guerra, Francisco M.

Moreno-Dorado, F. Javier

Jorge, Zacarias D.

Massanet, Guillermo M.

Sohoel, Helmer

Smitt, Ulla W.

Frydenvang, Karla

Christensen, S. Brogger

Nielsen, Charlotte

Eriksson, Margit

机构：

[1] Univ Cadiz, Fac Ciencias, Dept Quim Organ, Cadiz 11510, Spain

[2] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen O, Denmark

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 11期

关键词：

D O I：

10.1021/np0603065

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida Var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

引用

页码：1566 / 1571

页数：6

共 21 条

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