Enhanced expression of the mesenchymal marker, vimentin, in hyperplastic versus normal human prostatic epithelium

被引：41

作者：

Fraga, CH ^{[1
]}

True, LD ^{[1
]}

Kirk, D ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PATHOL, MED CTR, SEATTLE, WA USA

来源：

JOURNAL OF UROLOGY | 1998年 / 159卷 / 01期

关键词：

BPH; epithelium; mesenchyme; vimentin; cytokeratin;

D O I：

10.1016/S0022-5347(01)64080-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

A total of 20 benign prostatic hyperplasia (BPH) tissue samples from 13 patients were evaluated for the coexpression of cytokeratins and vimentin intermediate filaments in the glandular epithelium. Vimentin expression was significantly increased (p < 0.001) in BPH epithelium compared to adjacent ''normal'' epithelium. The data imply that epithelial/mesenchymal (E/M) transformations may play a role in the pathogenesis of BPH.

引用

页码：270 / 274

页数：5

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