Photo-acoustic imaging of microvascular structure in tissue

被引:6
作者
Pilatou, MC [1 ]
Kolkman, RGM [1 ]
Hondebrink, E [1 ]
Berendsen, R [1 ]
De Mul, FFM [1 ]
机构
[1] Univ Twente, Dept Appl Phys, Biophys Tech Grp, NL-7500 AE Enschede, Netherlands
来源
BIOMEDICAL OPTOACOUSTICS | 2000年 / 3916卷
关键词
photo-acoustics; array detector; microvascular structure; 3-D imaging;
D O I
10.1117/12.386340
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Our goal is the development of a photo-acoustic instrument for 3-D imaging of the microvascular structure in tissue, in real time. A photo-acoustic multi-element detector has been designed, which measures in reflection mode. The light source is a pulsed laser with a wavelength of 532nm and the active piezo-material is PVdF. Using a disk detector we have achieved to reconstruct 3-D images with a depth and lateral resolution of 10-20 mu m and 200 mu m respectively. With the new probe we expect to reduce the measuring time and to speed up the signal and image processing.
引用
收藏
页码:48 / 54
页数:7
相关论文
共 11 条
[1]   A REVIEW OF THE OPTICAL-PROPERTIES OF BIOLOGICAL TISSUES [J].
CHEONG, WF ;
PRAHL, SA ;
WELCH, AJ .
IEEE JOURNAL OF QUANTUM ELECTRONICS, 1990, 26 (12) :2166-2185
[2]   LASER-DOPPLER VELOCIMETRY AND MONTE-CARLO SIMULATIONS ON MODELS FOR BLOOD PERFUSION IN TISSUE [J].
DEMUL, FFM ;
KOELINK, MH ;
KOK, ML ;
HARMSMA, PJ ;
GREVE, J ;
GRAAFF, R ;
AARNOUDSE, JG .
APPLIED OPTICS, 1995, 34 (28) :6595-6611
[3]   A new theoretical approach to photoacoustic signal generation [J].
Hoelen, CGA ;
de Mul, FFM .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1999, 106 (02) :695-706
[4]   Imaging of cutaneaous blood vessels using photoacoustic tissue scanning (PATS) [J].
Hoelen, CGA ;
de Mul, FFM .
PHOTON PROPAGATION IN TISSUES IV, PROCEEDINGS, 1998, 3566 :134-142
[5]   Photoacoustic Tissue Scanning (PATS) [J].
Hoelen, CGA ;
Kolkman, RGM ;
Letteboer, M ;
Berendsen, R ;
de Mul, FFM .
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF, 1999, 3597 :336-343
[6]  
HOELEN CGA, 3 D PHOTOACOUSTIC TI, pCH5
[7]  
HOELEN CGA, 3 D PHOTOACOUSTIC TI, pCH2
[8]  
JACQUES SL, 1991, P SOC PHOTOOPT INSTR, V1422, P3
[9]   A photoacoustic photothermal optical fibre sensor for the minimally invasive detection of cancers and other tissue pathologies [J].
Laufer, J ;
Beard, P ;
Mills, T .
SPECIALTY FIBER OPTICS FOR MEDICAL APPLICATIONS, PROCEEDINGS OF, 1999, 3596 :217-224
[10]  
ORAEVSKY AA, 1995, SPIE, V2389, P198