Vancomycin architecture dependence on the capture efficiency of antibody-modified microbeads by magnetic nanoparticles

被引:25
作者
Kell, Arnold J. [1 ]
Simard, Benoit [1 ]
机构
[1] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada
关键词
D O I
10.1039/b617427b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We show that the ability to control the architecture/orientation of vancomycin on the surface of magnetic nanoparticles has a drastic effect on the ability of the nanoparticles to magnetically confine vancomycin-antibody modified polystyrene microbeads.
引用
收藏
页码:1227 / 1229
页数:3
相关论文
共 21 条
[1]   Structure-binding relationships for the interaction between a vancomycin monoclonal antibody fab fragment and a library of vancomycin analogues and tracers [J].
Adamczyk, M ;
Grote, J ;
Moore, JA ;
Rege, SD ;
Yu, ZG .
BIOCONJUGATE CHEMISTRY, 1999, 10 (02) :176-185
[2]   The use of nanocrystals in biological detection [J].
Alivisatos, P .
NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52
[3]   Biofunctional magnetic nanoparticles for protein separation and pathogen detection [J].
Gu, HW ;
Xu, KM ;
Xu, CJ ;
Xu, B .
CHEMICAL COMMUNICATIONS, 2006, (09) :941-949
[4]   Using biofunctionalized nanoparticles to probe pathogenic bacteria [J].
Ho, KC ;
Tsai, PJ ;
Lin, YS ;
Chen, YC .
ANALYTICAL CHEMISTRY, 2004, 76 (24) :7162-7168
[5]   Vancomycin assembly: Nature's way [J].
Hubbard, BK ;
Walsh, CT .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (07) :730-765
[6]   In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals [J].
Huh, YM ;
Jun, YW ;
Song, HT ;
Kim, S ;
Choi, JS ;
Lee, JH ;
Yoon, S ;
Kim, KS ;
Shin, JS ;
Suh, JS ;
Cheon, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (35) :12387-12391
[7]   Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery [J].
Kohler, N ;
Sun, C ;
Fichtenholtz, A ;
Gunn, J ;
Fang, C ;
Zhang, MQ .
SMALL, 2006, 2 (06) :785-792
[8]   Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells [J].
Kohler, N ;
Sun, C ;
Wang, J ;
Zhang, MQ .
LANGMUIR, 2005, 21 (19) :8858-8864
[9]   Ethylene glycol-protected magnetic nanoparticles for a multiplexed immunoassay in human plasma [J].
Lin, PC ;
Chou, PH ;
Chen, SH ;
Liao, HK ;
Wang, KY ;
Chen, YJ ;
Lin, CC .
SMALL, 2006, 2 (04) :485-489
[10]   Affinity capture using vancomycin-bound magnetic nanoparticles for the MALDI-MS analysis of bacteria [J].
Lin, YS ;
Tsai, PJ ;
Weng, MF ;
Chen, YC .
ANALYTICAL CHEMISTRY, 2005, 77 (06) :1753-1760