The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
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作者:
Castro, CP
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Castro, CP
Nagashima, AC
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Nagashima, AC
Pereda, MP
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Pereda, MP
Goldberg, V
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Goldberg, V
Chervin, A
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Chervin, A
Largen, P
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Largen, P
Renner, U
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Renner, U
Stalla, GK
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Stalla, GK
Arzt, E
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机构:Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
Arzt, E
机构:
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina
[2] Max Planck Inst Psychiat, Dept Endocrinol, D-80804 Munich, Germany
[3] Univ Buenos Aires, Fac Med, Inst Invest Med, RA-1427 Buenos Aires, DF, Argentina
[4] Hosp Santa Lucia, RA-1232 Buenos Aires, DF, Argentina
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin-6 (IL-6), which belong to the cytokine receptor family using the common gp130 signal transducer. We studied the actions of two other members of this family, IL-11 and ciliary neurotropic factor (CNTF), on folliculostellate (FS) cells (TtT/GF cell line) and lactosomatotropic cells (GH3 cell line). The messenger RNA (mRNA) for the or-chain specific for the IL-11 receptor (1.7 kb) and CNTF receptor (2 kb) are expressed on both cell types. In addition, we detected CNTF receptor mRNA in normal rat anterior pituitary cells. IL-11 (1.25-5 nM) dose dependently stimulated the proliferation of FS cells. CNTF, at doses from 0.4-2 nM, also significantly stimulated the growth of these cells. In addition, both cytokines significantly stimulated proliferation of lactosomatotropic GH3 cells, and CNTF stimulated hormone production (GH and PRL) at 24 h by these cells. At 16-72 h, IL-11 stimulates the secretion of the angiogenic factor vascular endothelial growth factor by FS cells.In addition, both GH3 and FS cells express CNTF mRNA. These data suggest Chat IL-11 and CNTF may act as growth and regulatory factors in anterior pituitary cells.
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UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USAUNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USA
Akita, S
Malkin, J
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UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USAUNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USA
Malkin, J
Melmed, S
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UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USAUNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USA
机构:
Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA
Auernhammer, CJ
Melmed, S
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Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA
机构:
UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USAUNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USA
Akita, S
Malkin, J
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UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USAUNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USA
Malkin, J
Melmed, S
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UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USAUNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90048 USA
机构:
Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA
Auernhammer, CJ
Melmed, S
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Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA