Cardiovascular effects of endocannabinoids -: the plot thickens

被引：41

作者：

Kunos, G ^{[1
]}

Járai, Z ^{[1
]}

Varga, K ^{[1
]}

Liu, J ^{[1
]}

Wang, L ^{[1
]}

Wagner, JA ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2000年 / 61卷 / 1-2期

关键词：

anandamide; 2-arachidonoyl glycerol; vasodilation; blood pressure;

D O I：

10.1016/S0090-6980(00)00056-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cannabinoids, the bioactive ingredients of the marijuana plant, are best known for their psychoactive properties, but they also influence other physiological processes, such as cardiovascular variables. Endocannabinoids are recently identified lipid mediators that act as natural ligands at cannabinoid receptors and mimic most of the biological effects, including the cardiovascular actions, of plant-derived cannabinoids. In experimental animals, the most prominent component of the cardiovascular effects of cannabinoids is prolonged hypotension and bradycardia. This review focuses on the possible mechanisms underlying these effects. The emerging evidence suggesting that endocannabinoids may be involved in the peripheral regulation of vascular tone under certain conditions is also discussed. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：71 / 84

页数：14

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