Eicosanoid Profile of Influenza A Virus Infected Pigs

被引：13

作者：

Schultz, Daniel ^{[1
]}

Methling, Karen ^{[1
]}

Rothe, Michael ^{[3
]}

Lalk, Michael ^{[1
]}

Blohm, Ulrike ^{[2
]}

Karte, Claudia ^{[2
]}

Koellner, Bernd ^{[2
]}

Schaefer, Alexander ^{[2
]}

Schroeder, Charlotte ^{[2
]}

Schwaiger, Theresa ^{[2
]}

Sehl, Julia ^{[2
]}

Ulrich, Reiner ^{[2
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Biochem, D-17487 Greifswald, Germany

[2] Friedrich Loeffler Inst, Suedufer 10, D-17493 Greifswald, Germany

[3] Lipidomix, D-13125 Berlin, Germany

来源：

METABOLITES | 2019年 / 9卷 / 07期

关键词：

eicosanoids; lipid mediator; Influenza A virus; infection; pig; ENDOGENOUS ARACHIDONIC-ACID; BIOACTIVE LIPIDS; INFLAMMATION; METABOLISM; LIPIDOMICS; MEDIATORS; LIPOXINS;

D O I：

10.3390/metabo9070130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Respiratory tract infections caused by the Influenza A virus (IAV) are a worldwide problem for human and animal health. Within this study, we analyzed the impact of IAV infection on the immune-related lipidome (eicosanoids) of the pig as new infection model. For this purpose, we performed HPLC-MS / MS using dynamic multiple reaction monitoring and analyzed lung, spleen, blood plasma and bronchoalveolar lavages. IAV infection leads to collective changes in the levels of the analyzed hydroxyeicosatrienoic acids (HETEs), hydroxydocosahexaenoic acids (HDHAs) and epoxyeicosatrienoic acids (EETs), and moreover, unique eicosanoid changes in several sample types, even under mild infection conditions. In accordance with di ff erent mouse infection studies, we observed infection-related patterns for 12-HETE, 15-HETE and 17-HDHA, which seem to be common for IAV infection. Using a long-term approach of 21 days we established an experimental setup that can be used also for bacterial-viral coinfection experiments.

引用

页数：10

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