In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188

被引：21

作者：

Espuelas, S

Legrand, P

Loiseau, PM

Bories, C

Barratt, C

Irache, JM ^{[1
]}

机构：

[1] Univ Navarra, Fac Farm, Dept Farm & Tecnol Farmaceut, E-31080 Pamplona, Spain

[2] Univ Paris Sud, Fac Pharm, UMR 86, F-92296 Chatenay Malabry, France

[3] Univ Paris Sud, Fac Pharm, UPRES EA 398, F-92296 Chatenay Malabry, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 08期

关键词：

D O I：

10.1128/AAC.44.8.2190-2192.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.

引用

页码：2190 / 2192

页数：3

共 24 条

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