Compressibility and volume changes of lysozyme due to guanidine hydrochloride denaturation

被引：19

作者：

Kamiyama, T ^{[1
]}

Gekko, K ^{[1
]}

机构：

[1] HIROSHIMA UNIV, FAC SCI, DEPT MAT SCI, HIGASHIHIROSHIMA, HIROSHIMA 739, JAPAN

来源：

CHEMISTRY LETTERS | 1997年 / 10期

关键词：

D O I：

10.1246/cl.1997.1063

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The apparent specific volume and adiabatic compressibility of lysozyme largely decreased upon guanidine hydrochloride denaturation. These results demonstrate that a large amount of amino acid residues exposes accompanying an increase in hydration and a decrease in the internal cavity. Both parameters deviated from the two-state transition curves, suggesting noncooperative disruption of the compactness and the secondary structure.

引用

页码：1063 / 1064

页数：2

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