Tracking T cells with tetramers: New tales from new tools

被引：146

作者：

Klenerman, P

Cerundolo, V

Dunbar, RR

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford OX1 1SY, England

[2] John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DU, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nri777

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

To understand the success or failure of immune responses against pathogens or tumours requires the direct measurement of specific lymphocytes. Recently, there has been an explosion of data in this field through the use of several new tools for measuring the number and function of T cells. This has allowed immunologists who study human disease and mouse models of infection and cancer to readily track specific T cells - in both time and space. Although there are common patterns, overtime, each host-pathogen relationship seems to develop unique characteristics, as reflected in the quality of the T-cell response.

引用

收藏

页码：263 / 272

页数：10

相关论文

共 116 条

[1]

Tumor-specific killer cells in paraneoplastic cerebellar degeneration [J].

Albert, ML ;

Darnell, JC ;

Bender, A ;

Francisco, LM ;

Bhardwaj, N ;

Darnell, RB .

NATURE MEDICINE, 1998, 4 (11) :1321-1324

[2]

CD8+ lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule Mamu-A*01:: Implications for vaccine design and testing [J].

Allen, TM ;

Mothé, BR ;

Sidney, J ;

Jing, PC ;

Dzuris, JL ;

Liebl, ME ;

Vogel, TU ;

O'Connor, DH ;

Wang, XC ;

Wussow, MC ;

Thomson, JA ;

Altman, JD ;

Watkins, DI ;

Sette, A .

JOURNAL OF VIROLOGY, 2001, 75 (02) :738-749

[3]

Phenotypic analysis of antigen-specific T lymphocytes [J].

Altman, JD ;

Moss, PAH ;

Goulder, PJR ;

Barouch, DH ;

McHeyzerWilliams, MG ;

Bell, JI ;

McMichael, AJ ;

Davis, MM .

SCIENCE, 1996, 274 (5284) :94-96

[4]

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses [J].

André, P ;

Groettrup, M ;

Klenerman, P ;

de Giuli, R ;

Booth, BL ;

Cerundolo, V ;

Bonneville, M ;

Jotereau, F ;

Zinkernagel, RM ;

Lotteau, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13120-13124

[5]

An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions [J].

Anichini, A ;

Molla, A ;

Mortarini, R ;

Tragni, G ;

Bersani, I ;

Di Nicola, M ;

Gianni, AM ;

Pilotti, S ;

Dunbar, R ;

Cerundolo, V ;

Parmiani, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (05) :651-667

[6]

HIV-specific CD8+ T cells produce antiviral cytokines but are impaired in cytolytic function [J].

Appay, V ;

Nixon, DF ;

Donahoe, SM ;

Gillespie, GMA ;

Dong, T ;

King, A ;

Ogg, GS ;

Spiegel, HML ;

Conlon, C ;

Spina, CA ;

Havlir, DV ;

Richman, DD ;

Waters, A ;

Easterbrook, P ;

McMichael, AJ ;

Rowland-Jones, SL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (01) :63-75

[7]

APPAY V, NATURE MED, V8, P379

[8]

Characteristics of virus-specific CD8+ T cells in the liver during the control and resolution phases of influenza pneumonia [J].

Belz, GT ;

Altman, JD ;

Doherty, PC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13812-13817

[9]

Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection [J].

Belz, GT ;

Doherty, PC .

JOURNAL OF VIROLOGY, 2001, 75 (09) :4435-4438

[10]

In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers [J].

Benlagha, K ;

Weiss, A ;

Beavis, A ;

Teyton, L ;

Bendelac, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (11) :1895-1903

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