Nociceptin: An endogenous agonist for central opioid like(1) (ORL(1)) receptors possesses systemic vasorelaxant properties

被引：57

作者：

Gumusel, B

Hao, QZ

Hyman, A

Chang, JK

Kapusta, DR

Lippton, H

机构：

[1] HL LABS INC, NEW ORLEANS, LA 70112 USA

[2] TULANE UNIV, DEPT SURG MED & PHARMACOL, NEW ORLEANS, LA 70112 USA

[3] PHOENIX PHARMACEUT INC, MT VIEW, CA 94043 USA

[4] LOUISIANA STATE UNIV, DEPT PHARMACOL, NEW ORLEANS, LA 70112 USA

来源：

LIFE SCIENCES | 1997年 / 60卷 / 08期

关键词：

orphanin FQ; blood vessels; systemic vasculature; peptide vasorelaxation; cat;

D O I：

10.1016/S0024-3205(96)00696-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3x10(-11) - 3x10(-6) M) decreased tension in a concentration-dependent manner. The present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow.

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收藏

页码：PL141 / PL145

页数：5

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