Signal transduction to hypoxia-inducible factor 1

被引：702

作者：

Semenza, GL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21287 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2002年 / 64卷 / 5-6期

关键词：

growth factor; MAP kinase; phosphatidylinositol; 3-kinase; prolyl hydroxylase; receptor tyrosine kinase;

D O I：

10.1016/S0006-2952(02)01168-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypoxia-inducible factor I (HIF-1) is a transcriptional activator that functions as a master regulator of O-2 homeostasis. HIF-1 target,genes encode proteins that increase O-2 delivery and mediate adaptive responses to O-2 deprivation. HIF-1 activity is regulated by the cellular O-2 concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：993 / 998

页数：6

共 67 条

[1] Aebersold DM, 2001, CANCER RES, V61, P2911
[2] Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Bhattacharya, S
Michels, CL
Leung, MK
Arany, ZP
Kung, AL
Livingston, DM
[J]. GENES & DEVELOPMENT, 1999, 13 (01) : 64 - 75
[3] Birner P, 2000, CANCER RES, V60, P4693
[4] Birner P, 2001, CLIN CANCER RES, V7, P1661
[5] Birner P, 2001, CANCER, V92, P165, DOI 10.1002/1097-0142(20010701)92:1<165::AID-CNCR1305>3.0.CO
[6] 2-F
[7] Levels of hypoxia-inducible factor-1α during breast carcinogenesis
Bos, R
Zhong, H
Hanrahan, CF
Mommers, ECM
Semenza, GL
Pinedo, HM
Abeloff, MD
Simons, JW
van Diest, PJ
van der Wall, E
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (04): : 309 - 314
[8] A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, RK
McKnight, SL
[J]. SCIENCE, 2001, 294 (5545) : 1337 - 1340
[9] Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
Bruick, RK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) : 9082 - 9087
[10] Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3
Caniggia, I
Mostachfi, H
Winter, J
Gassmann, M
Lye, SJ
Kuliszewski, M
Post, M
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (05) : 577 - 587

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