Studies of ion-exchange resin complex of chloroquine phosphate

被引：52

作者：

Agarwal, R ^{[1
]}

Mittal, R ^{[1
]}

Singh, A ^{[1
]}

机构：

[1] Panacea Biotec Ltd, Punjab 140501, India

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2000年 / 26卷 / 07期

关键词：

chloroquine phosphate; drug release; ion-exchange resin; stability; taste masking;

D O I：

10.1081/DDC-100101297

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High-potency adsorbates of chloroquine phosphate (CQP) were prepared by the batch method using a polyacrylic acid ion-exchange resin. Taste evaluation of the adsorbates shows significant masking of the bitterness of the drug. The complex formation was complete at pH 6.0. Stability studies at 37 degrees C, 45 degrees C,and 60 degrees C indicated that the complex was stable at all conditions for 1 month. In vitro release studies revealed complete drug elution from the complex at pH 1.2 and 2.0.

引用

页码：773 / 776

页数：4

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